Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain

Mitochondrial maintenance crucially depends on the quality control of proteins by various chaperones, proteases and repair enzymes. While most of the involved components have been studied in some detail, little is known on the biological role of the CLPXP protease complex located in the mitochondrial matrix. Here we show that deletion of PaClpP, encoding the CLP protease proteolytic subunit CLPP, leads to an unexpected healthy phenotype and increased lifespan of the fungal ageing model organism Podospora anserina. This phenotype can be reverted by expression of human ClpP in the fungal deletion background, demonstrating functional conservation of human and fungal CLPP. Our results show that the biological role of eukaryotic CLP proteases can be studied in an experimentally accessible model organism

Order-disorder transition in swirled granular disks

We study the order-disorder transition of horizontally swirled dry and wet granular disks by means of computer simulations. Our systematic investigation of the local order formation as a function of amplitude and period of the external driving force shows that a large cluster of hexagonally ordered particles forms for both dry and wet granular particles at intermediate driving energies. Disordered states are found at small and large driving energies. Wet granular particles reach a higher degree of local hexagonal order, with respect to the dry case. For both cases we report a qualitative phase diagram showing the amount of local order at different state points. Furthermore we find that the transition from hexagonal order to a disordered state is characterised by the appearance of particles with square local order.Comment: 7 pages, 9 Figure

Steffen Wippel, Katrin Bromber, Christian Steiner & Birgit Krawietz: “Under Construction: Logics of Urbanism in the Gulf Region”

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Florida\u27s Community Notification of Sex Offenders on the Internet: The Disregard of Constitutional Protections for Sex Offenders

One of the toughest challenges for the courts is determining how to balance society\u27s need for protection against an individual\u27s constitutional rights. This Note provides an analysis of the controversy concerning community notification of sex offenders who victimize children, with the discussion directed to the constitutionality of community notification over the Internet, and suggests other possible ways to help prevent repeat sex offenses against children. Part II begins by focusing on which members of our communities are sex offenders that victimize children and looks at the reasons why they choose children as their victims. In Part III, this Note traces the development of community notification laws by focusing on the Federal Violent Crime Control and Law Enforcement Act of 1994, which was based on New Jersey\u27s Megan\u27s Law, and then examines Florida\u27s recently enacted Sexual Predator Act. Part IV discusses constitutional challenges in general and then analyzes how federal and state courts have applied them to statutes that allow for community notification and registration of sex offenders. In conjunction with the discussion of these constitutional challenges, this Note extends the analysis to Florida\u27s unchallenged statute which allows the law enforcement to provide community notification on the Internet. In Part V, this Note looks to other methods of dealing with society\u27s fear of sex offenders that would not violate the Constitution

Florida\u27s Community Notification of Sex Offenders on the Internet: The Disregard of Constitutional Protections for Sex Offenders

One of the toughest challenges for the courts is determining how to balance society\u27s need for protection against an individual\u27s constitutional rights. This Note provides an analysis of the controversy concerning community notification of sex offenders who victimize children, with the discussion directed to the constitutionality of community notification over the Internet, and suggests other possible ways to help prevent repeat sex offenses against children. Part II begins by focusing on which members of our communities are sex offenders that victimize children and looks at the reasons why they choose children as their victims. In Part III, this Note traces the development of community notification laws by focusing on the Federal Violent Crime Control and Law Enforcement Act of 1994, which was based on New Jersey\u27s Megan\u27s Law, and then examines Florida\u27s recently enacted Sexual Predator Act. Part IV discusses constitutional challenges in general and then analyzes how federal and state courts have applied them to statutes that allow for community notification and registration of sex offenders. In conjunction with the discussion of these constitutional challenges, this Note extends the analysis to Florida\u27s unchallenged statute which allows the law enforcement to provide community notification on the Internet. In Part V, this Note looks to other methods of dealing with society\u27s fear of sex offenders that would not violate the Constitution